The method of our time is to use not one but multiple exploration models.

Marshall McLuhan

Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice (Garcia S et al., 2015) (pdf)

Achondroplasia is a rare disease where bone growth is stunted and cartilage does not form correctly. It is caused by a mutation in the gene that encodes fibroblast growth factor receptor 3 (FGFR3), which leads to overactive receptor signaling. Yet, despite knowing the cause, a treatment has not been discovered.

In an innovative approach, Garcia and colleagues used receptor ”decoys” to prevent the FGF ligand from binding its mutated receptor, thus interrupting the signaling cascade and restoring bone growth in mice.

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